Never go off an antidepressant on your own without your doctor’s OK, because stopping too quickly can lead to a resurgence of symptoms and other side effects. Whether you’re currently dealing with antidepressant-induced sleep fallout, or you want help for your depression but would rather avoid sleep issues if possible, the first step is to talk to your doctor, Breus says. For example, a doctor may advise a patient to take a sedating antidepressant at nighttime. Vivid dreams may persist for some people, but lots of times, these sleep issues will subside after a couple of weeks, he adds. “Most people will tell you they mainly see when they first start, then it goes away,” Winter says. In some cases, however, antidepressants cause side effects that dont go away. The side effects of Wellbutrin may include: Nausea. For many people, these improve within weeks of starting an antidepressant. Yes, but it should be taken with caution as it has possible side effects. Signs and symptoms such as nausea, weight gain or sleep problems can be common initially. These sleep-related side effects often aren’t permanent. Antidepressants can cause unpleasant side effects. If you’re freaked out by how your antidepressant has affected your sleep (or how one might in the future), there’s some good news. Other types of antidepressants can bring about either fatigue or insomnia as side effects. That can result in feeling extra-energized, potentially causing insomnia, Breus says. On the other side of the spectrum, norepinephrine and dopamine reuptake inhibitors, like the popular drug bupropion (Wellbutrin), increase the levels of those two neurotransmitters in the brain. “When somebody is taking an SSRI, they have more serotonin in their system for longer, which can have a sedating effect,” leading to sleepiness. “Serotonin is a calming hormone,” Breus says. Bupropion is a prescription medication used to treat major depressive disorder (MDD) and seasonal affective disorder (SAD). Take selective serotonin reuptake inhibitors (SSRIs), like sertraline (Zoloft) and paroxetine (Paxil). “All of these chemicals are big players in the pathways of maintaining or initiating sleep, or chemicals that help you feel awake during the day,” Winter says. These neurotransmitters play another role as well. Chris Winter, M.D., of Charlottesville Neurology and Sleep Medicine and author of The Sleep Solution, tells SELF. The most common side effects of WELLBUTRIN XL include: trouble sleeping, stuffy nose, dry mouth, dizziness, feeling anxious, nausea, constipation, and joint. “Generally speaking, these medications affect neurotransmitters like serotonin, dopamine, and norepinephrine,” which are important for regulating your emotions, board-certified sleep medicine doctor and neurologist W. Although different people can react to the same medication in different ways, there are some basic rules for how various antidepressants might influence your sleep.
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